Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Lee SH, Turpin W, Espin-Garcia O, Raygoza Garay JA, Smith MI, Leibovitzh H, Goethel A, Turner D, Mack D, Deslandres C, Cino M, Aumais G, Panaccione R, Jacobson K, Bitton A, Steinhart AH, Huynh HQ, Princen F, Moayyedi P, Griffiths AM, Silverberg MS, Paterson AD, Xu W, Croitoru K; CCC GEM  Project Research Consortium. Gastroenterology. 2021 Nov;161(5):1540-1551. doi: 10.1053/j.gastro.2021.07.009. read full article here

Increased Intestinal Permeability is Associated with Later Development of Crohn’s Disease

Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB., Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart HA, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Croitoru K; CCC GEM Project Research Consortium

Gastroenterology. 2020 Aug 10:S0016-5085(20)35021-6. doi:10.1053/j.gastro.2020.08.005.

read full article here

Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

Robertson SJ, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, Guttman DS, Croitoru K, Girardin SE, Philpott DJ

 2019 May 7;27(6):1910-1919.e2. doi: 10.1016/j.celrep.2019.04.023.

Read the full article here

Nod2 influences microbial resilience and susceptibility to colitis following antibiotic exposure

Goethel A, Turpin W, Rouquier S, Zanello G, Robertson SJ, Streutker CJ, Philpott DJ, and Croitoru K.

 2019 May;12(3):720-732. doi: 10.1038/s41385-018-0128-y. Epub 2019 Jan 16.

Read the full article
Commentary by Dr. Timothy Borbet and Dr. Martin Blaser can be found here

FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.

Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MA, GUttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart H, Aumais G, Shestopaloff K, Dieleman LA, Turner D, Paterson AD, Croitoru K.

Gut Microbes. 2018 Mar 13:1-24. doi: 10.1080/19490976.2018.1445956. Epub ahead of print.


Association of Host Genome with Intestinal Microbial Composition in a Large Healthy Cohort.

Turpin W, Espin-Garcia O, Xu W, Silverberg MS, Kevans D, Smith MI, Guttman DS, Griffiths A, Panancionne R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G, The GEM Project Research Consortium, Paterson AD, Croitoru K.

Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.


Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

Zanello G, Goethel A, Forster K, Geddes K, Philpott DJ, Croitoru K.

PLoS One. 2013 Dec 6;8(12):e82623. doi: 10.1371/journal.pone.0082623. eCollection 2013.


Microbiome analysis – from technical advances to biological relevance.

Smith MI, Turpin W, Tyler AD, Silverberg MS, Croitoru K.

F1000Prime Rep. 2014 Jul 8;6:51. doi: 10.12703/P6-51. eCollection 2014.


Determinants of intestinal permeability in healthy first-degree relatives of individuals with Crohn’s disease.

Kevans D, Turpin W, Madsen K, Meddings J, Shestopaloff K, Xu W, Moreno-Hagelsieb G, Griffiths A, Silverberg MS, Paterson A, Croitoru K; GEM Project.

Inflamm Bowel Dis. 2015 Apr;21(4):879-87. doi: 10.1097/MIB.0000000000000323.


IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn’s Disease Patients.

Kevans D, Silverberg MS, Borowski K, Griffiths A, Xu W, Onay V, Paterson AD, Knight J, Croitoru K; GEM Project.

J Crohns Colitis. 2016 Feb;10(2):209-15. doi: 10.1093/ecco-jcc/jjv197. Epub 2015 Oct 28.


The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy.

Zanello G, Goethel A, Rouquier S, Prescott D, Robertson SJ, Maisonneuve C, Streutker C, Philpott DJ, Croitoru K.

J Immunol. 2016 Jul 1;197(1):345-55. doi: 10.4049/jimmunol.1600185. Epub 2016 May 20.