Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives
Raygoza Garay JA, Turpin W, Lee SH, Smith MI, Goethel A, Griffiths AM, Moayyedi P, Espin-Garcia O, Abreu M, Aumais GL, Bernstein CN, Biron IA, Cino M, Deslandres C, Dotan I, El-Matary W, Feagan B, Guttman DS, Huynh H, Dieleman LA, Hyams JS, Jacobson K, Mack D, Marshall JK, Otley A, Panaccione R, Ropeleski M, Silverberg MS, Steinhart AH, Turner D, Yerushalmi B, Paterson AD, Xu W; CCC GEM Project Research Consortium; Croitoru K. Gut Microbiome Composition is associated with future onset of Crohn’s Disease in Healthy First-Degree Relatives. Gastroenterology. 2023 May 30:S0016-5085(23)00805-3. doi: 10.1053/j.gastro.2023.05.032.
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis.
Leibovitzh H, Lee SH, Raygoza Garay JA, Espin-Garcia O, Xue M, Neustaeter A, Goethel A, Huynh HQ, Griffiths AM, Turner D, Madsen KL, Moayyedi P, Steinhart AH, Silverberg MS, Deslandres C, Bitton A, Mack DR, Jacobson K, Cino M, Aumais G, Bernstein CN, Panaccione R, Weiss B, Halfvarson J, Xu W, Turpin W, Croitoru K; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium. Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis. Gut. 2023 Feb 14:gutjnl-2022-328421. doi: 10.1136/gutjnl-2022-328421.
Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis
Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, Sheppard D, Sands BE, Porter CK, Croitoru K, Petralia F; CCC-GEM Project Research Consortium; OSCCAR Consortium; Colombel JF, Mehandru S. Anti-integrin αvβ6 autoantibodies are a novel biomarker that antedate ulcerative colitis. Gastroenterology. 2023 Jan 9: S0016-5085(23)00010-0. https://doi.org/10.1053/j.gastro.2022.12.042. Epub ahead of print.
Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease
Leibovitzh H, Lee SH, Xue M, Raygoza Garay JA, Hernandez-Rocha C, Madsen KL, Meddings JB, Guttman DS, Espin-Garcia O, Smith MI, Goethel A, Griffiths AM, Moayyedi P, Steinhart AH, Panancionne R, Huynh H, Jacobson K, Aumais G, Mack DR, Abreu M, Bernstein CN, Marshall JK, Turner D, Xu W; CCC GEM Project Research Consortium, Turpin W, Croitoru K. Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn’s disease. Gastroenterology. 2022 Jul 15: 163(5):163(5):1364-1376.e10. Advance online publication. https://doi.org/10.1053/j.gastro.2022.07.004
Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation
Turpin, W., Dong, M., Sasson, G., Raygoza Garay, J. A., Espin-Garcia, O., Lee, S. H., Neustaeter, A., Smith, M. I., Leibovitzh, H., Guttman, D. S., Goethel, A., Griffiths, A. M., Huynh, H. Q., Dieleman, L. A., Panaccione, R., Steinhart, A. H., Silverberg, M. S., Aumais, G., Jacobson, K., Mack, D., … Croitoru, K. (2022). Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation. Gastroenterology, 163(3), 685–698. https://doi.org/10.1053/j.gastro.2022.05.037
Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD-Prediction and Prevention of Inflammatory Bowel Disease
Torres J, Halfvarson J, Rodríguez-Lago I, Hedin CR, Jess T, Dubinsky M, Croitoru K, & Colombel J-F. Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Prediction and Prevention of Inflammatory Bowel Disease. Journal of Crohn’s and Colitis. 2021 Mar; 15(9): 1443–1454. https://doi.org/10.1093/ecco-jcc/jjab048
Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk
Lee SH, Turpin W, Espin-Garcia O, Raygoza Garay JA, Smith MI, Leibovitzh H, Goethel A, Turner D, Mack D, Deslandres C, Cino M, Aumais G, Panaccione R, Jacobson K, Bitton A, Steinhart AH, Huynh HQ, Princen F, Moayyedi P, Griffiths AM, Silverberg MS, Paterson AD, Xu W, Croitoru K; CCC GEM Project Research Consortium. Gastroenterology. 2021 Nov;161(5):1540-1551. doi: 10.1053/j.gastro.2021.07.009. https://pubmed.ncbi.nlm.nih.gov/34293299/ read full article here
Increased Intestinal Permeability is Associated with Later Development of Crohn’s Disease
Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB., Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart HA, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Croitoru K; CCC GEM Project Research Consortium
Gastroenterology. 2020 Aug 10:S0016-5085(20)35021-6. doi:10.1053/j.gastro.2020.08.005.
https://pubmed.ncbi.nlm.nih.gov/32791132/
read full article here
Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models
Robertson SJ, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, Guttman DS, Croitoru K, Girardin SE, Philpott DJ
Cell Rep. 2019 May 7;27(6):1910-1919.e2. doi: 10.1016/j.celrep.2019.04.023.
https://www.ncbi.nlm.nih.gov/pubmed/31067473
Read the full article here
Nod2 influences microbial resilience and susceptibility to colitis following antibiotic exposure
Goethel A, Turpin W, Rouquier S, Zanello G, Robertson SJ, Streutker CJ, Philpott DJ, and Croitoru K.
Mucosal Immunol. 2019 May;12(3):720-732. doi: 10.1038/s41385-018-0128-y. Epub 2019 Jan 16.
https://www.ncbi.nlm.nih.gov/pubmed/30651577
Read the full article
Commentary by Dr. Timothy Borbet and Dr. Martin Blaser can be found here
FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.
Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MA, GUttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart H, Aumais G, Shestopaloff K, Dieleman LA, Turner D, Paterson AD, Croitoru K.
Gut Microbes. 2018 Mar 13:1-24. doi: 10.1080/19490976.2018.1445956. Epub ahead of print.
https://www.ncbi.nlm.nih.gov/pubmed/29533703
Association of Host Genome with Intestinal Microbial Composition in a Large Healthy Cohort.
Turpin W, Espin-Garcia O, Xu W, Silverberg MS, Kevans D, Smith MI, Guttman DS, Griffiths A, Panancionne R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G, The GEM Project Research Consortium, Paterson AD, Croitoru K.
Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
https://www.ncbi.nlm.nih.gov/pubmed/27694960
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
Zanello G, Goethel A, Forster K, Geddes K, Philpott DJ, Croitoru K.
PLoS One. 2013 Dec 6;8(12):e82623. doi: 10.1371/journal.pone.0082623. eCollection 2013.
http://www.ncbi.nlm.nih.gov/pubmed/24324812
Microbiome analysis – from technical advances to biological relevance.
Smith MI, Turpin W, Tyler AD, Silverberg MS, Croitoru K.
F1000Prime Rep. 2014 Jul 8;6:51. doi: 10.12703/P6-51. eCollection 2014.
http://www.ncbi.nlm.nih.gov/pubmed/25184041
Determinants of intestinal permeability in healthy first-degree relatives of individuals with Crohn’s disease.
Kevans D, Turpin W, Madsen K, Meddings J, Shestopaloff K, Xu W, Moreno-Hagelsieb G, Griffiths A, Silverberg MS, Paterson A, Croitoru K; GEM Project.
Inflamm Bowel Dis. 2015 Apr;21(4):879-87. doi: 10.1097/MIB.0000000000000323.
http://www.ncbi.nlm.nih.gov/pubmed/25734694
IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn’s Disease Patients.
Kevans D, Silverberg MS, Borowski K, Griffiths A, Xu W, Onay V, Paterson AD, Knight J, Croitoru K; GEM Project.
J Crohns Colitis. 2016 Feb;10(2):209-15. doi: 10.1093/ecco-jcc/jjv197. Epub 2015 Oct 28.
http://www.ncbi.nlm.nih.gov/pubmed/26512135
The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy.
Zanello G, Goethel A, Rouquier S, Prescott D, Robertson SJ, Maisonneuve C, Streutker C, Philpott DJ, Croitoru K.
J Immunol. 2016 Jul 1;197(1):345-55. doi: 10.4049/jimmunol.1600185. Epub 2016 May 20.
http://www.ncbi.nlm.nih.gov/pubmed/27206769
