Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk
This study aimed to assess whether an altered host immune reactivity to microbial antigens could trigger the onset of Crohn’s Disease (CD). Findings from the study suggest that, even after adjusting for confounding factors, an increased anti-microbial antibody response was associated with the risk of future onset of CD, proposing that anti-microbial antibody responses may potentially be an early pre-disease event. In comparison to the samples from healthy controls, the pre-CD samples showed significantly elevated levels of all 6 individual antibodies against bacterial and fungal antigens, thus demonstrating the differences in anti-microbial reactivity responses.
Lee SH, Turpin W, Espin-Garcia O, Raygoza Garay JA, Smith MI, Leibovitzh H, Goethel A, Turner D, Mack D, Deslandres C, Cino M, Aumais G, Panaccione R, Jacobson K, Bitton A, Steinhart AH, Huynh HQ, Princen F, Moayyedi P, Griffiths AM, Silverberg MS, Paterson AD, Xu W, Croitoru K; CCC GEM Project Research Consortium. Gastroenterology. 2021 Nov;161(5):1540-1551. doi: 10.1053/j.gastro.2021.07.009. https://pubmed.ncbi.nlm.nih.gov/34293299/ read full article here