PUBLICATIONS

This study assessed whether long term dietary patterns could be associated with changes in the gut bacteria composition and gut inflammation in a cohort of first-degree relatives of patients with Crohn’s disease. The results showed that a Mediterranean-like dietary pattern were associated with a distinct gut bacteria composition which had increased abundance of fibre degrading bacteria, as well as lower gut inflammation as defined by fecal-calprotectin. It was determined that the reduction in gut inflammation was due to a direct effect of the Mediterranean-like dietary pattern, as well as indirectly through the diet induced changes to the gut bacteria population. Turpin, W., Dong, M., Sasson, G., Raygoza Garay, J. A., Espin-Garcia, O., Lee, S. H., Neustaeter, A., Smith, M. I., Leibovitzh, H., Guttman, D. S., Goethel, A., Griffiths, A. M., Huynh, H. Q., Dieleman, L. A., Panaccione, R., Steinhart, A. H., Silverberg, M. S., Aumais, G., Jacobson, K., Mack, D., … Croitoru, K. (2022). Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation. Gastroenterology, 163(3), 685–698. https://doi.org/10.1053/j.gastro.2022.05.037