People

Bhupesh is deeply interested in exploring the complex interplay between host genetics, gut microbiota, the immune system, and dietary factors at the intestinal mucosa to understand the pathogenesis of gastrointestinal diseases, including colorectal cancer. His Ph.D. thesis focused on the regulation of the expression and signaling of pattern recognition receptors at the intestinal mucosa in relation to mucosal immune homeostasis and gastrointestinal infections. At the University of Toronto, he is currently investigating how gut microbiota and dietary factors interact to dysregulate mucosal immune responses, leading to gastrointestinal diseases and cancer, using both animal models and clinical samples. He also employs single-cell immunophenotyping and multi-omics data analysis to uncover immune dysregulation that precedes the clinical onset of Crohn’s disease (CD). His research aims to develop prognostic biomarkers and diet- or microbiota-based preventive and therapeutic strategies for gastrointestinal diseases.